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USC-OGP 2-DE database
Two-dimensional polyacrylamide gel electrophoresis database
USC-OGP 2-DE database
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Searching in 'USC-OGP 2-DE database' for entry
matching:
P04075
USC-OGP 2-DE database
:
P04075
P04075
General information about the entry
View entry in simple text format
Entry name
ALDOA_HUMAN
Primary accession number
P04075
integrated into USC-OGP 2-DE database on
January 17, 2017 (release 1)
2D Annotations were last modified on
January 17, 2017 (version 1)
General Annotations were last modified on
April 5, 2017 (version 2)
Name and origin of the protein
Description
RecName: Full=Fructose-bisphosphate aldolase A; EC=4.1.2.13; AltName: Full=Lung cancer antigen NY-LU-1; AltName: Full=Muscle-type aldolase;.
Gene name
Name=ALDOA
Synonyms=ALDA
Annotated species
Homo sapiens (Human) [TaxID:
9606
]
Taxonomy
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
References
[1]
2D GEL CHARACTERIZATION
Author 1., Author 2.
Submitted (Mar-2011) to Current
2D PAGE maps for identified proteins
How to interpret a protein
PLATELET_6-11
{PLATELET 6-11}
Homo sapiens (Human)
map experimental info
PLATELET_6-11
MAP LOCATIONS:
SPOT OGP-0959
:
pI=7.41; Mw=39238
SPOT OGP-0960
:
pI=7.51; Mw=39238
SPOT OGP-0961
:
pI=7.62; Mw=39146
SPOT OGP-0962
:
pI=8.01; Mw=38871
SPOT OGP-0963
:
pI=7.83; Mw=38780
UVEAL_MELANOMA_3-10
{UVEAL MELANOMA 3-10}
Homo sapiens (Human)
map experimental info
UVEAL_MELANOMA_3-10
MAP LOCATIONS:
SPOT OGP-1200
:
pI=7.15; Mw=39675
Cross-references
UniProtKB/Swiss-Prot
P04075; ALDOA_HUMAN.
2D PAGE maps for identified proteins
How to interpret a protein map
You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw.
Warning 1
: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly.
Warning 2
: the 2D PAGE map is built on demand. This may take some few seconds to be computed.
External data extracted from
UniProtKB/Swiss-Prot
Extracted from
UniProtKB/Swiss-Prot
, release:
0.0
Entry name
ALDOA_HUMAN
Primary accession number
P04075
Secondary accession number(s)
B4DXI7 Q6FH76 Q6FI10 Q96B15 Q9BWD9 Q9UCN2
Sequence was last modified on
January 23, 2007 (version 2)
Annotations were last modified on
March 15, 2017 (version 207)
Name and origin of the protein
Description
RecName: Full=Fructose-bisphosphate aldolase A; EC=4.1.2.13; AltName: Full=Lung cancer antigen NY-LU-1; AltName: Full=Muscle-type aldolase;
Gene name
Name=ALDOA
Synonyms=ALDA
Encoded on
Name=ALDOA; Synonyms=ALDA
Keywords
3D-structure
;
Acetylation
;
Alternative splicing
;
Complete proteome
;
Cytoplasm
;
Direct protein sequencing
;
Disease mutation
;
Glycogen storage disease
;
Glycolysis
;
Hereditary hemolytic anemia
;
Isopeptide bond
;
Lyase
;
Phosphoprotein
;
Polymorphism
;
Reference proteome
;
Schiff base
;
Ubl conjugation
.
Copyright
Copyrighted by the UniProt Consortium, see
http://www.uniprot.org/help/license
. Distributed under the Creative Commons Attribution-NoDerivs License
Cross-references
EMBL
M11560; AAA51690.1
; -; mRNA
EMBL
X05236; CAA28861.1
; -; mRNA
EMBL
X12447; CAA30979.1
; -; Genomic_DNA
EMBL
AK301993; BAG63399.1
; -; mRNA
EMBL
CR536528; CAG38765.1
; -; mRNA
EMBL
CR541880; CAG46678.1
; -; mRNA
EMBL
AC093512; -
; NOT_ANNOTATED_CDS; Genomic_DNA
EMBL
CH471238; EAW79933.1
; -; Genomic_DNA
EMBL
BC000367; AAH00367.2
; -; mRNA
EMBL
BC004333; AAH04333.1
; -; mRNA
EMBL
BC010660; AAH10660.1
; -; mRNA
EMBL
BC012880; AAH12880.1
; -; mRNA
EMBL
BC013614; AAH13614.1
; -; mRNA
EMBL
BC015888; AAH15888.1
; -; mRNA
EMBL
BC016170; AAH16170.1
; -; mRNA
EMBL
BC016800; AAH16800.1
; -; mRNA
EMBL
M21190; AAA51697.1
; -; mRNA
CCDS
CCDS10668.1; -. [P04075-1]
; .
CCDS
CCDS58450.1; -. [P04075-2]
; .
PIR
S14084; ADHUA
; .
RefSeq
NP_000025.1; NM_000034.3. [P04075-1]
; .
RefSeq
NP_001121089.1; NM_001127617.2. [P04075-1]
; .
RefSeq
NP_001230106.1; NM_001243177.1. [P04075-2]
; .
RefSeq
NP_908930.1; NM_184041.2. [P04075-1]
; .
RefSeq
NP_908932.1; NM_184043.2. [P04075-1]
; .
RefSeq
XP_011544070.1; XM_011545768.2. [P04075-1]
; .
UniGene
Hs.513490; -
; .
UniGene
Hs.732822; -
; .
PDB
1ALD; X-ray
; 2.00 A; A=2-364
PDB
2ALD; X-ray
; 2.10 A; A=2-364
PDB
4ALD; X-ray
; 2.80 A; A=2-364
PDBsum
1ALD; -
; .
PDBsum
2ALD; -
; .
PDBsum
4ALD; -
; .
ProteinModelPortal
P04075; -
; .
SMR
P04075; -
; .
BioGrid
106728; 111
; .
IntAct
P04075; 37
; .
MINT
MINT-4998828; -
; .
STRING
9606.ENSP00000336927; -
; .
ChEMBL
CHEMBL2106; -
; .
DrugBank
DB08240; N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE
; .
iPTMnet
P04075; -
; .
PhosphoSitePlus
P04075; -
; .
SwissPalm
P04075; -
; .
BioMuta
ALDOA; -
; .
DMDM
113606; -
; .
DOSAC-COBS-2DPAGE
P04075; -
; .
OGP
P04075; -
; .
REPRODUCTION-2DPAGE
IPI00465439; -
; .
REPRODUCTION-2DPAGE
P04075; -
; .
SWISS-2DPAGE
P04075; -
; .
UCD-2DPAGE
P04075; -
; .
EPD
P04075; -
; .
PaxDb
P04075; -
; .
PeptideAtlas
P04075; -
; .
PRIDE
P04075; -
; .
TopDownProteomics
P04075-1; -. [P04075-1]
; .
DNASU
226; -
; .
Ensembl
ENST00000338110; ENSP00000336927
; ENSG00000149925. [P04075-1]; .
Ensembl
ENST00000395248; ENSP00000378669
; ENSG00000149925. [P04075-2]; .
Ensembl
ENST00000412304; ENSP00000400452
; ENSG00000149925. [P04075-1]; .
Ensembl
ENST00000563060; ENSP00000455800
; ENSG00000149925. [P04075-1]; .
Ensembl
ENST00000564546; ENSP00000455917
; ENSG00000149925. [P04075-1]; .
Ensembl
ENST00000564595; ENSP00000457468
; ENSG00000149925. [P04075-2]; .
Ensembl
ENST00000566897; ENSP00000455724
; ENSG00000149925. [P04075-1]; .
Ensembl
ENST00000569545; ENSP00000455700
; ENSG00000149925. [P04075-1]; .
GeneID
226; -
; .
KEGG
hsa:226; -
; .
UCSC
uc010veg.3; human. [P04075-1]
; .
CTD
226; -
; .
DisGeNET
226; -
; .
GeneCards
ALDOA; -
; .
HGNC
HGNC:414; ALDOA
; .
HPA
CAB006252; -
; .
HPA
HPA004177; -
; .
MalaCards
ALDOA; -
; .
MIM
103850; gene
; .
MIM
611881; phenotype
; .
neXtProt
NX_P04075; -
; .
OpenTargets
ENSG00000149925; -
; .
Orphanet
57; Glycogen storage disease due to aldolase A deficiency
; .
PharmGKB
PA24707; -
; .
eggNOG
KOG1557; Eukaryota
; .
eggNOG
COG3588; LUCA
; .
GeneTree
ENSGT00390000010235; -
; .
HOVERGEN
HBG002386; -
; .
InParanoid
P04075; -
; .
KO
K01623; -
; .
OMA
PNMVIDG; -
; .
OrthoDB
EOG091G0A9T; -
; .
PhylomeDB
P04075; -
; .
TreeFam
TF314203; -
; .
BioCyc
MetaCyc:HS07647-MONOMER; -
; .
BRENDA
4.1.2.13; 2681
; .
Reactome
R-HSA-114608; Platelet degranulation
; .
Reactome
R-HSA-6798695; Neutrophil degranulation
; .
Reactome
R-HSA-70171; Glycolysis
; .
Reactome
R-HSA-70263; Gluconeogenesis
; .
SABIO-RK
P04075; -
; .
UniPathway
UPA00109; UER00183
; .
EvolutionaryTrace
P04075; -
; .
GeneWiki
Aldolase_A; -
; .
GenomeRNAi
226; -
; .
PRO
PR:P04075; -
; .
Proteomes
UP000005640; Chromosome 16
; .
Bgee
ENSG00000149925; -
; .
CleanEx
HS_ALDOA; -
; .
ExpressionAtlas
P04075; baseline and differential
; .
Genevisible
P04075; HS
; .
GO
GO:0015629; C:actin cytoskeleton
; IDA:BHF-UCL; .
GO
GO:0005829; C:cytosol
; IDA:HPA; .
GO
GO:0070062; C:extracellular exosome
; IDA:UniProtKB; .
GO
GO:0005576; C:extracellular region
; TAS:Reactome; .
GO
GO:0005615; C:extracellular space
; IDA:UniProtKB; .
GO
GO:1904813; C:ficolin-1-rich granule lumen
; TAS:Reactome; .
GO
GO:0031674; C:I band
; TAS:BHF-UCL; .
GO
GO:0031430; C:M band
; IEA:UniProtKB-SubCell; .
GO
GO:0016020; C:membrane
; IDA:UniProtKB; .
GO
GO:0005634; C:nucleus
; IDA:UniProtKB; .
GO
GO:0031093; C:platelet alpha granule lumen
; TAS:Reactome; .
GO
GO:0034774; C:secretory granule lumen
; TAS:Reactome; .
GO
GO:1904724; C:tertiary granule lumen
; TAS:Reactome; .
GO
GO:0003779; F:actin binding
; TAS:BHF-UCL; .
GO
GO:0045296; F:cadherin binding
; IDA:BHF-UCL; .
GO
GO:0008092; F:cytoskeletal protein binding
; IDA:BHF-UCL; .
GO
GO:0070061; F:fructose binding
; IDA:BHF-UCL; .
GO
GO:0004332; F:fructose-bisphosphate aldolase activity
; IDA:BHF-UCL; .
GO
GO:0042802; F:identical protein binding
; IPI:IntAct; .
GO
GO:0003723; F:RNA binding
; IDA:UniProtKB; .
GO
GO:0015631; F:tubulin binding
; TAS:BHF-UCL; .
GO
GO:0007015; P:actin filament organization
; TAS:BHF-UCL; .
GO
GO:0006754; P:ATP biosynthetic process
; IMP:BHF-UCL; .
GO
GO:0061621; P:canonical glycolysis
; TAS:Reactome; .
GO
GO:0030388; P:fructose 1
; 6-bisphosphate metabolic process; IDA:BHF-UCL
GO
GO:0006000; P:fructose metabolic process
; IMP:BHF-UCL; .
GO
GO:0006094; P:gluconeogenesis
; TAS:Reactome; .
GO
GO:0006096; P:glycolytic process
; IMP:BHF-UCL; .
GO
GO:0046716; P:muscle cell cellular homeostasis
; IMP:BHF-UCL; .
GO
GO:0043312; P:neutrophil degranulation
; TAS:Reactome; .
GO
GO:0002576; P:platelet degranulation
; TAS:Reactome; .
GO
GO:0051289; P:protein homotetramerization
; ISS:UniProtKB; .
GO
GO:0008360; P:regulation of cell shape
; IDA:BHF-UCL; .
GO
GO:0006941; P:striated muscle contraction
; IMP:BHF-UCL; .
Gene3D
3.20.20.70; -
; 1; .
InterPro
IPR029768; Aldolase_I_AS
; .
InterPro
IPR013785; Aldolase_TIM
; .
InterPro
IPR000741; FBA_I
; .
Pfam
PF00274; Glycolytic
; 1; .
PROSITE
PS00158; ALDOLASE_CLASS_I
; 1; .
Gateways to other related servers
The World-2DPAGE Constellation
- Entry point to the world-wide 2-DPAGE resources.
World-2DPAGE Repository
- A public repository for gel-based proteomics data linked to protein identification published in the literature.
World-2DPAGE Portal
- A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
SWISS-2DPAGE
- The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
ExPASy
- The resources web server of the
Swiss Institute of Bioinformatics
Database constructed and maintained by
Angel Garcia
, using the
Make2D-DB II
package (
ver. 3.10.2
) from the
World-2DPAGE Constellation
of the
ExPASy web server
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